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Rapamune

Brand Names

; Rapamune®

Immunosuppressant Agent

You will have an increased risk of getting infections. Avoid crowds and people with infections, colds, or flu.

This medicine prevents the body's rejection after a kidney transplant. It is used in combination with other medicines to help the body accept the new organ.

Sirolimus decreases the body's response to a transplanted kidney. It quiets the immune system.

To gain the most benefit, do not miss doses.
Take with or without food, but be consistent. Always take with food or always take on an empty stomach.
Avoid grapefruit and grapefruit juice.
Take this medicine 4 hours after cyclosporine capsules (Neoral®) or oral solution (Neoral®).
Oral solution:
- Put 1/4 cup of water or orange juice into a glass or plastic container.
- Measure the medicine in the oral dose syringe. Empty medicine from syringe into container. Mix well and drink now.
- Fill container again with 1/4 cup of water or orange juice. Mix well and drink now.
Medicine in the pouch:
- Put 1/4 cup of water or orange juice into a glass or plastic container.
- Empty medicine from the pouch into the container. Squeeze it all out.
- Mix well and drink now.
- Fill container again with 1/4 cup of water or orange juice. Mix well and drink now.

Take a missed dose as soon as possible.
If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
Do not take a double dose or extra doses.
Do not change dose or stop taking medicine without talking with healthcare provider.

Check all medicines with healthcare provider. This medicine may not mix well with other medicines.
Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
Do not use in pregnancy and do not get pregnant. Use birth control that you can trust. Start it before this medicine is started, while taking this medicine, and for 3 months after this medicine is stopped.
Do not use if you are breast-feeding.

Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat.
Fever and/or chills.
Severe headache.
Severe diarrhea.
Unusual bruising or bleeding.
Feeling worse.

Store in a refrigerator. Protect from light. Once the bottle is opened, it should be used in 1 month.
You can store your medicine at room temperature for several days, but no longer than 1 month.
Medicine drawn up in a syringe can be kept at room temperature for 24 hours. Throw the syringe away after use.
The oral solution may look hazy when refrigerated. Bring up to room temperature and shake gently until haze goes away. Then take medicine.

Do not share your medicine with others and do not take anyone else's medicine.
Keep all medicine out of the reach of children and pets.
Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).