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Metolazone
Brand Names
; Mykrox® ; Zaroxolyn®Therapeutic Categories
Diuretic, ThiazideReasons not to take this medicine
- If you have an allergy to another thiazide, sulfonamide, metolazone, or any other part of the medicine.
- If you have severe kidney disease or coma because of liver failure.
- If you are pregnant.
What is this medicine used for?
- This medicine is used for the treatment of high blood pressure. It gets rid of extra fluid (salt and water) in the body.
How does it work?
- Metolazone lowers blood pressure and gets rid of extra salt and water in the body by acting on the kidneys.
How is it best taken?
- Take with food early in the day. This prevents getting up at night to use the bathroom.
What do I do if I miss a dose?
- Take a missed dose as soon as possible.
- If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
- Do not take a double dose or extra doses.
What are the precautions when taking this medicine?
- Avoid alcohol (includes wine, beer, and liquor). Can worsen high blood pressure or fluid gain.
- Use caution if you are diabetic. Talk with healthcare provider. Can increase glucose.
- Not for use in kidney disease. Talk with healthcare provider.
- Watch for gout attacks. If you have sudden pain in a single joint, like the toe, talk with healthcare provider.
- You can get sunburned more easily. Avoid lots of sun. Use sunscreen; wear protective clothing and eyewear.
- Do not use over-the-counter products that increase blood pressure. These include cough or cold remedies, diet pills, stimulants, ibuprofen or like products, and certain herbs or supplements. Talk with healthcare provider.
- Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
- Tell healthcare provider if you are pregnant or plan on getting pregnant.
- Tell healthcare provider if you are breast-feeding.
What are the common side effects of this medicine?
- Lightheaded. Avoid driving, doing other tasks or activities that require you to be alert until you see how this medicine affects you.
- Dizziness is common. Rise slowly over several minutes from sitting or lying position. Be careful climbing stairs.
- Dry mouth. Frequent mouth care, sucking hard candy, or chewing gum may help.
- Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard candy, or chewing gum may help.
- Low potassium. This may make you feel tired, weak, or have numbness, tingling, muscle cramps, constipation, vomiting, or rapid heartbeats. May require taking supplements and/or eating foods rich in potassium. Talk with healthcare provider.
What should I monitor?
- If you are using this medicine for fluid removal, check daily weight. Report a weight gain or loss.
- Check blood sugar as ordered by healthcare provider.
- Check blood pressure regularly.
- Follow diet plan (low salt) and exercise program as recommended by healthcare provider.
- Check blood work (potassium). Talk with healthcare provider.
Reasons to call healthcare provider immediately
- Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, or throat.
- Passing out, fainting, dizziness, or lightheadedness.
- Signs of low potassium (see above). Can lead to serious heartbeat problems.
- Severe nausea, vomiting, and/or diarrhea.
- Any rash.
How should I store this medicine?
- Store in a tight, light-resistant container at room temperature.
General statements
- Do not share your medicine with others and do not take anyone else's medicine.
- Keep all medicine out of the reach of children and pets.
- Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
- Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).






